منابع مشابه
Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor a (RARa) and oncogenic RARa fusion proteins
*Centre National de la Recherche Scientifique, Unité Propre de Recherche 9051, Laboratoire associé N°11 du comité de Paris de la ligue nationale contre le cancer, conventionné par l’Université de Paris VII, Hôpital St. Louis, 75475 Paris Cedex 10, France; and §Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique-Institut National de la San...
متن کاملUrotensin 2 and retinoic acid receptor alpha (RARA) gene expression in IgA nephropathy.
INTRODUCTION IgA nephropathy is a disease where the pathogenesis is still poorly understood. Deoxyribonucleic acid (DNA) microarray technique allows tens of thousands of gene expressions to be examined at the same time. Commercial availability of microarray genechips has made this powerful tool accessible for wider utilisation in the study of diseases. MATERIALS AND METHODS Seven patients wit...
متن کاملAccelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway.
Acute promyelocytic leukemia (APL) is associated with a chromosomal translocation t(15;17) and successfully differentiated by all-trans-retinoic acid (ATRA) in vivo as well as in vitro. The PML-retinoic acid receptor alpha (RARA) oncoprotein, which is generated by the translocation, blocks the differentiation, and ATRA is thought to modulate the dominant negative function of PML-RARA. However, ...
متن کاملOpposite Effects of the Acute Promyelocytic Leukemia PML-Retinoic Acid Receptor a (RARa) and PLZF-RARa Fusion Proteins on Retinoic Acid Signalling
MARTIN RUTHARDT, UGO TESTA, CLARA NERVI, PIER FRANCESCO FERRUCCI, FRANCESCO GRIGNANI, ELENA PUCCETTI, FAUSTO GRIGNANI, CESARE PESCHLE, AND PIER GIUSEPPE PELICCI* Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Istituto di Medicina Interna e Scienze Oncologiche, Policlinico Monteluce, Perugia University, 06100 Perugia, Department of Haematology and Oncology, Ist...
متن کاملThe retinoic acid receptor alpha (RARA) gene is not associated with myopia, hypermetropia, and ocular biometric measures
PURPOSE The Retinoic Acid Receptor Alpha (RARA) gene is a potential candidate gene for myopia due to its differential expression in animal models during experimentally induced myopia. To test for whether RARA is associated with myopia we have undertaken a case-control study assessing for associations between RARA and myopia, hypermetropia, and ocular biometric measures. METHODS A total of 802...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/37670